European Association of Systems Medicine

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14 research positions in the EU Horizon 2020 Marie Skłodowska-Curie MSCA-ETN project COSMIC www.cosmic-h2020.eu

Applications are invited for 14 ESRs (Early Stage Researchers) funded by the H2020 Marie-Sklodowska-Curie European Training Network COSMIC (Combatting disorders of adaptive immunity with systems medicine; project 765158) within the European Horizon 2020 Programme. COSMIC is an international consortium of high profile universities, research institutions and companies. We are looking for 13 PhD positions and 1 industrial researcher

 

Keywords

Systems medicine, adaptive immunity, germinal centre, B-cell lymphoma, rheumatoid arthritis, computational modelling

Research consortium

Academic Medical Center (Amsterdam, NL; Coordinator), Research Centre Inria (Lyon, FR), Karolinska Institute (Stockholm, SE), Babraham Institute (Cambridge, UK), FIRC institute of molecular oncology (Milan, IT), Anaxomics Biotech SL (Barcelona, ES), Redoxis AB (Lund, SE), Helmoltz Centre for Infection Research (Braunschweig, DE), IBM (Zurich, CH), Centre for Research and Technology Hellas (Thessaloniki, EL)

Partner Organisations

Elevate Health (NL), KNIME AG (CH), SURFsara (NL), Science Matters (NL), DTL data projects (NL), Immunowell (IW), Vivia Biotech (ES)

Research programme

COSMIC aims to deliver the next generation of leading, entrepreneurial, and creative systems medicine professionals having expertise, skills, and experience to successfully combat complex human disorders. In COSMIC we will focus on B-cell lymphoma (BCL) and rheumatoid arthritis (RA), diseases that originate from abnormal functioning of immune cells.

COSMIC is a systems medicine project. Systems medicine recently emerged as a new concept added to the toolbox of clinical and biomedical research to address key questions in complex human diseases such as BCL and RA. It pursues an integrative and holistic approach by involving different sectors, integrating disciplines, and combining experimental and computational approaches. We focus on mechanisms of immunological memory and antibody formation as part of the adaptive immune system, and how these are involved in the pathogenesis of BCL and RA.

The adaptive immune system is a key component of our defence against pathogens and comprises highly specialised cells and processes. Its humoral component is responsible for memory B-cell formation and high-affinity antibody production resulting from affinity maturation in germinal centres (GC). GCs are specialised anatomical sites typically found in secondary lymphoid tissues where immune cells interact, differentiate and undergo antibody gene alterations. Perturbations of the GC reaction contribute to the emergence transformed/malignant cells that give rise to BCL, or clones expressing autoreactive antibodies involved in RA pathogenesis. Despite recent progress, a precise understanding of the dynamics of the GC reaction and its role in BCL and RA pathogenesis has yet to emerge. The complexity of the GC will be addressed by the development, application and integration of computational and experimental approaches. COSMIC aims to elucidate the cellular and molecular mechanisms of the GC reaction to understand the development and evolution of BCL and RA. This is expected to lead to the identification of markers that can be exploited for preventive, diagnostic, and/or (personalised) therapeutic purposes to achieve best outcome and leverage the cost-effectiveness of treatment.

Profile

We look for ESRs with a master degree in life sciences, immunology, bioinformatics, computational sciences, or similar. Precise requirements can be found with the 14 job descriptions on the website. The candidates should have a keen interest immunology, experimental and computational approaches, and systems medicine.

Career stage
We accept applications from Early Stage Researcher (ESR) with less than 4 years research experience and no doctoral degree. Please read carefully the minimum eligibility criteria listed on the website.

Benefits and salary

The Marie Skłodowska-Curie (MSCA) programme offers a highly competitive and attractive salary and working conditions. The successful candidates will receive a salary in accordance with the MSCA regulations for early stage researchers. Exact salary will be confirmed upon appointment [Living Allowance = €37.320/year (correction factor to be applied per country) + Monthly mobility allowance = €600. An additional monthly allowance of €500 is applicable depending on family situation. In addition to their individual scientific projects, all fellows will benefit from further continuing education, which includes internships and secondments, a variety of training modules as well as transferable skills courses and active participation in workshops and conferences.

Online recruitment

All applications proceed through the on-line recruitment portal on the COSMIC website. Candidates can apply electronically for up to three positions indicating their preference. Candidates are requested to provide all information regarding eligibility (ESR definition, mobility criteria, English language proficiency), plus a detailed CV, motivation letter, grades, and optionally 1-2 references. The deadline for on-line registration is shown on the website.

Further information

Laurian Jongejan, PhD (COSMIC project manager)
Academic Medical Center, University of Amsterdam
E-mail: l.zuidmeer@amc.uva.nl

Information, job description, and online application: http://www.cosmic-h2020.eu

COSMIC organisations act in line with the principles of the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers. COSMIC intends to hire an equal number of male and female ESRs. Selected ESRs will start within a couple of months after the interview date, and preferably no later than September 1st, 2018.